Design and Synthesis of Highly Active Antimycobacterial Mutual Esters of 2-(2-Isonicotinoylhydrazineylidene)propanoic Acid

• المؤلفون الرئيسيون: Václav Pflégr (مؤلف), Jana Maixnerová (مؤلف), Jiřina Stolaříková (مؤلف), Adrián Pál (مؤلف), Jana Korduláková (مؤلف), František Trejtnar (مؤلف), Jarmila Vinšová (مؤلف), Martin Krátký (مؤلف)
• التنسيق: كتاب
• منشور في: MDPI AG, 2021-12-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

The combination of two active scaffolds into one molecule represents a proven approach in drug design to overcome microbial drug resistance. We designed and synthesized more lipophilic esters of 2-(2-isonicotinoylhydrazineylidene)propanoic acid, obtained from antitubercular drug isoniazid, with vari...