Design and Synthesis of Highly Active Antimycobacterial Mutual Esters of 2-(2-Isonicotinoylhydrazineylidene)propanoic Acid

• Main Authors: Václav Pflégr (Author), Jana Maixnerová (Author), Jiřina Stolaříková (Author), Adrián Pál (Author), Jana Korduláková (Author), František Trejtnar (Author), Jarmila Vinšová (Author), Martin Krátký (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The combination of two active scaffolds into one molecule represents a proven approach in drug design to overcome microbial drug resistance. We designed and synthesized more lipophilic esters of 2-(2-isonicotinoylhydrazineylidene)propanoic acid, obtained from antitubercular drug isoniazid, with vari...