Integrative HLA typing of tumor and adjacent normal tissue can reveal insights into the tumor immune response

• Main Authors: Angelina Sverchkova (Author), Scott Burkholz (Author), Reid Rubsamen (Author), Richard Stratford (Author), Trevor Clancy (Author)
• Format: Book
• Published: BMC, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The HLA complex is the most polymorphic region of the human genome, and its improved characterization can help us understand the genetics of human disease as well as the interplay between cancer and the immune system. The main function of HLA genes is to recognize "non-self&...