Optical Recording of Action Potentials in Human Induced Pluripotent Stem Cell-Derived Cardiac Single Cells and Monolayers Generated from Long QT Syndrome Type 1 Patients

• Main Authors: Tadashi Takaki (Author), Azusa Inagaki (Author), Kazuhisa Chonabayashi (Author), Keiji Inoue (Author), Kenji Miki (Author), Seiko Ohno (Author), Takeru Makiyama (Author), Minoru Horie (Author), Yoshinori Yoshida (Author)
• Format: Book
• Published: Hindawi Limited, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Induced pluripotent stem cells (iPSCs) from type 1 long QT (LQT1) patients can differentiate into cardiomyocytes (CMs) including ventricular cells to recapitulate the disease phenotype. Although optical recordings using membrane potential dyes to monitor action potentials (APs) were reported, no stu...