γ-Glutamyl-Transpeptidase-Resistant Glutathione Analog Attenuates Progression of Alzheimer's Disease-like Pathology and Neurodegeneration in a Mouse Model

• मुख्य लेखकों: Ye In Christopher Kwon (लेखक), Wei Xie (लेखक), Haizhou Zhu (लेखक), Jiashu Xie (लेखक), Keaton Shinn (लेखक), Nicholas Juckel (लेखक), Robert Vince (लेखक), Swati S. More (लेखक), Michael K. Lee (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2021-11-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Oxidative stress in Alzheimer's disease (AD) is mediated, in part, by the loss of glutathione (GSH). Previous studies show that γ-glutamyl transpeptidase (GGT)-resistant GSH analog, Ψ-GSH, improves brain GSH levels, reduces oxidative stress markers in brains of APP/PS1 transgenic mice, a mouse...