Subversion of innate defenses by the interplay between DENV and pre-existing enhancing antibodies: TLRs signaling collapse.

• Ngā kaituhi matua: Naphak Modhiran (Author), Siripen Kalayanarooj (Author), Sukathida Ubol (Author)
• Hōputu: Pukapuka
• I whakaputaina: Public Library of Science (PLoS), 2010-01-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

BACKGROUND: The phenomenon of antibody dependent enhancement as a major determinant that exacerbates disease severity in DENV infections is well accepted. While the detailed mechanism of antibody enhanced disease severity is unclear, evidence suggests that it is associated with both increased DENV i...