Cefminox, a Dual Agonist of Prostacyclin Receptor and Peroxisome Proliferator-Activated Receptor-Gamma Identified by Virtual Screening, Has Therapeutic Efficacy against Hypoxia-Induced Pulmonary Hypertension in Rats

Prostacyclin receptor (IP) and peroxisome proliferator-activated receptor-gamma (PPARγ) are both potential targets for treatment of pulmonary arterial hypertension (PAH). Expression of IP and PPARγ decreases in PAH, suggesting that screening of dual agonists of IP and PPARγ might be an efficient met...

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Main Authors: Jingwen Xia (Author), Li Yang (Author), Liang Dong (Author), Mengjie Niu (Author), Shengli Zhang (Author), Zhiwei Yang (Author), Gulinuer Wumaier (Author), Ying Li (Author), Xiaomin Wei (Author), Yi Gong (Author), Ning Zhu (Author), Shengqing Li (Author)
Format: Knjiga
Izdano: Frontiers Media S.A., 2018-02-01T00:00:00Z.
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