Bafetinib Suppresses the Transcription of PD-L1 Through c-Myc in Lung Cancer

• Main Authors: Xi Chen (Author), Qianqian Du (Author), Hongjie Guo (Author), Qiaojun He (Author), Bo Yang (Author), Ling Ding (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Given the limitations of the existing antibody-based therapies, including immune-related adverse events, poor response rates, and intravenous route of dosing, small molecules inhibitors targeting PD-L1 are highly desirable. By cell-based screening, we found that tyrosine kinase inhibitor Bafetinib d...