The Traditional Japanese Herbal Medicine Hachimijiogan Elicits Neurite Outgrowth Effects in PC12 Cells and Improves Cognitive in AD Model Rats via Phosphorylation of CREB

• Main Authors: Kaori Kubota (Author), Haruka Fukue (Author), Hitomi Sato (Author), Kana Hashimoto (Author), Aya Fujikane (Author), Hiroshi Moriyama (Author), Takuya Watanabe (Author), Shutaro Katsurabayashi (Author), Mosaburo Kainuma (Author), Katsunori Iwasaki (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hachimijiogan (HJG) is a traditional herbal medicine that improves anxiety disorders in patients with dementia. In this study, we tested the hypothesis that HJG exerts neurotrophic factor-like effects to ameliorate memory impairment in Alzheimer disease (AD) model rats. First, we describe that HJG a...