Novel mutations in genes of the IL-12/IFN-γ axis cause susceptibility to tuberculosis

• Main Authors: Sajjad Ahmad (Author), Jawad Ahmed (Author), Eman H. Khalifa (Author), Farhad Ali Khattak (Author), Anwar Sheed khan (Author), Syed Umar Farooq (Author), Sannaa M.A. Osman (Author), Magdi M. Salih (Author), Nadeem Ullah (Author), Taj Ali Khan (Author)
• Format: Book
• Published: Elsevier, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: The IL-12/23/ISG15-IFN-γ pathway is the main immunological pathway for controlling intra-macrophagic microorganisms such as Mycobacteria, Salmonella, and Leishmania spp. Consequently, upon mutations in genes of the IL-12/23/ISG15-IFN-γ pathway cause increased susceptibility to intra-macr...