Role of nutrients and mTOR signaling in the regulation of pancreatic progenitors development

• Main Authors: Lynda Elghazi (Author), Manuel Blandino-Rosano (Author), Emilyn Alejandro (Author), Corentin Cras-Méneur (Author), Ernesto Bernal-Mizrachi (Author)
• Format: Bog
• Udgivet: Elsevier, 2017-06-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

Objective: Poor fetal nutrition increases the risk of type 2 diabetes in the offspring at least in part by reduced embryonic β-cell growth and impaired function. However, it is not entirely clear how fetal nutrients and growth factors impact β-cells during development to alter glucose homeostasis an...