The G Protein Biased Small Molecule Apelin Agonist CMF-019 is Disease Modifying in Endothelial Cell Apoptosis In Vitro and Induces Vasodilatation Without Desensitisation In Vivo

Signaling through the apelin receptor is beneficial for a number of diseases including pulmonary arterial hypertension. The endogenous small peptides, apelin and elabela/toddler, are downregulated in pulmonary arterial hypertension but are not suitable for exogenous administration owing to a lack of...

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Main Authors: Cai Read (Author), Duuamene Nyimanu (Author), Peiran Yang (Author), Rhoda E. Kuc (Author), Thomas L. Williams (Author), Christopher M. Fitzpatrick (Author), Richard Foster (Author), Robert C. Glen (Author), Janet J. Maguire (Author), Anthony P. Davenport (Author)
Format: Book
Published: Frontiers Media S.A., 2021-01-01T00:00:00Z.
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3rd Floor Main Library

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