Analytical methodologies for sensing catechol-O-methyltransferase activity and their applications

• Main Authors: Fang-Yuan Wang (Author), Ping Wang (Author), Dong-Fang Zhao (Author), Frank J. Gonzalez (Author), Yu-Fan Fan (Author), Yang-Liu Xia (Author), Guang-Bo Ge (Author), Ling Yang (Author)
• Format: Book
• Published: Elsevier, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mammalian catechol-O-methyltransferases (COMT) are an important class of conjugative enzymes, which play a key role in the metabolism and inactivation of catechol neurotransmitters, catechol estrogens and a wide range of endobiotics and xenobiotics that bear the catechol group. Currently, COMT inhib...