Synthesis and biological evaluation of ortho-phenyl phenylhydroxamic acids containing phenothiazine with improved selectivity for class IIa histone deacetylases

• Main Authors: Kai-Cheng Hsu (Author), Yun-Yi Huang (Author), Jung-Chun Chu (Author), Yu-Wen Huang (Author), Jing-Lan Hu (Author), Tony Eight Lin (Author), Shih-Chung Yen (Author), Jing-Ru Weng (Author), Wei-Jan Huang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Class IIa histone deacetylases (HDACs) have been linked to tumorigenesis in various cancers. Previously, we designed phenylhydroxamic acid LH4f as a potent class IIa HDAC inhibitor. However, it also unselectively inhibited class I and class IIb HDACs. To enhance the compound's selectivity towar...