Design and evaluation of an extended-release matrix tablet formulation; the combination of hypromellose acetate succinate and hydroxypropylcellulose

• Κύριοι συγγραφείς: Sachiko Fukui (Συγγραφέας), Hideki Yano (Συγγραφέας), Shuichi Yada (Συγγραφέας), Tsuyoshi Mikkaichi (Συγγραφέας), Hidemi Minami (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Elsevier, 2017-03-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

The purpose of this study was to develop an extended-release (ER) matrix tablet that shows robust dissolution properties able to account for the variability of pH and mechanical stress in the GI tract using a combination of enteric polymer and hydrophilic polymer. Hypromellose acetate succinate (HPM...