Placenta mesenchymal stem cell-derived extracellular vesicles alleviate liver fibrosis by inactivating hepatic stellate cells through a miR-378c/SKP2 axis

• Main Authors: Wenjie Zheng (Author), Saiyan Bian (Author), Shi Qiu (Author), Colin E. Bishop (Author), Meimei Wan (Author), Nuo Xu (Author), Xieyin Sun (Author), Russel Clive Sequeira (Author), Anthony Atala (Author), Zhifeng Gu (Author), Weixin Zhao (Author)
• Format: Book
• Published: BMC, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Extracellular vesicles derived from mesenchymal stem/stromal cells (MSCs) have shown therapeutic effects on liver fibrosis. This study aimed to evaluate the effects of extracellular vesicles from placenta-derived MSCs (Pd-MSCs-EVs) on liver fibrosis at 3D/2D levels and explore th...