miR21 modulates the Hippo signaling pathway via interference with PP2A Bβ to inhibit trophoblast invasion and cause preeclampsia

• Main Authors: Mingyu Hu (Author), Yangxi Zheng (Author), Jiujiang Liao (Author), Li Wen (Author), Juan Cheng (Author), Jiayu Huang (Author), Biao Huang (Author), Li Lin (Author), Yao Long (Author), Yue Wu (Author), Xuan Ye (Author), Yong Fu (Author), Hongbo Qi (Author), Philip N. Baker (Author), Chao Tong (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Preeclampsia (PE) is a pregnancy-specific disorder attributed to deficient extravillous trophoblast (EVT) invasion into the uterus, but the mechanism of EVT invasion remains unclear. In this study, we found significantly elevated expression of microRNA 21 (miR21), which negatively regulates trophobl...