Oxidative Stress Plays an Important Role in Glutamatergic Excitotoxicity-Induced Cochlear Synaptopathy: Implication for Therapeutic Molecules Screening

• Main Authors: Anissa Rym Saidia (Author), Florence François (Author), François Casas (Author), Ilana Mechaly (Author), Stéphanie Venteo (Author), Joseph T. Veechi (Author), Jérôme Ruel (Author), Jean-Luc Puel (Author), Jing Wang (Author)
• Format: Book
• Published: MDPI AG, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The disruption of the synaptic connection between the sensory inner hair cells (IHCs) and the auditory nerve fiber terminals of the type I spiral ganglion neurons (SGN) has been observed early in several auditory pathologies (e.g., noise-induced or ototoxic drug-induced or age-related hearing loss)....