The Novel Small Molecule STK899704 Promotes Senescence of the Human A549 NSCLC Cells by Inducing DNA Damage Responses and Cell Cycle Arrest

• Main Authors: Chan-Woo Park (Author), Yesol Bak (Author), Min-Je Kim (Author), Ganipisetti Srinivasrao (Author), Joonsung Hwang (Author), Nak K. Sung (Author), Bo Yeon Kim (Author), Jae-Hyuk Yu (Author), Jin Tae Hong (Author), Do-Young Yoon (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The novel synthetic compound designated STK899704 (PubChem CID: 5455708) suppresses the proliferation of a broad range of cancer cell types. However, the details of its effect on lung cancer cells are unclear. We investigated the precise anticancer effect of STK899704 on senescence and growth arrest...