Inhibition of the CDK9-cyclin T1 protein-protein interaction as a new approach against triple-negative breast cancer

• Main Authors: Sha-Sha Cheng (Author), Yuan-Qing Qu (Author), Jia Wu (Author), Guan-Jun Yang (Author), Hao Liu (Author), Wanhe Wang (Author), Qi Huang (Author), Feng Chen (Author), Guodong Li (Author), Chun-Yuen Wong (Author), Vincent Kam Wai Wong (Author), Dik-Lung Ma (Author), Chung-Hang Leung (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cyclin-dependent kinase 9 (CDK9) activity is correlated with worse outcomes of triple-negative breast cancer (TNBC) patients. The heterodimer between CDK9 with cyclin T1 is essential for maintaining the active state of the kinase and targeting this protein-protein interaction (PPI) may offer promisi...