Inhibitory Effect of Matrine on Blood-Brain Barrier Disruption for the Treatment of Experimental Autoimmune Encephalomyelitis

• Main Authors: Su Zhang (Author), Quan-Cheng Kan (Author), Yuming Xu (Author), Guang-Xian Zhang (Author), Lin Zhu (Author)
• Format: Knjiga
• Izdano: Hindawi Limited, 2013-01-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Dysfunction of the blood-brain barrier (BBB) is a primary characteristic of experimental autoimmune encephalomyelitis (EAE), an experimental model of multiple sclerosis (MS). Matrine (MAT), a quinolizidine alkaloid derived from the herb Radix Sophorae Flave, has been recently found to suppress clini...