A combination of stromal PD‐L1 and tumoral nuclear β‐catenin expression as an indicator of colorectal carcinoma progression and resistance to chemoradiotherapy in locally advanced rectal carcinoma

• Main Authors: Hiroyuki Takahashi (Author), Hirono Watanabe (Author), Miki Hashimura (Author), Toshihide Matsumoto (Author), Ako Yokoi (Author), Mayu Nakagawa (Author), Yu Ishibashi (Author), Takashi Ito (Author), Kensuke Ohhigata (Author), Makoto Saegusa (Author)
• Format: Book
• Published: Wiley, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Programmed cell death‐1 (PD‐1) and its ligand (PD‐L1) are significant mediators of immune suppression in the tumor microenvironment. We focused on the immunological impact of PD‐1/PD‐L1 signaling during tumor progression in colorectal carcinoma (CRC) and its association with resistance to n...