Novel RNA Duplex Locks HIV-1 in a Latent State via Chromatin-mediated Transcriptional Silencing

• Main Authors: Chantelle Ahlenstiel (Author), Catalina Mendez (Author), Steven T H Lim (Author), Katherine Marks (Author), Stuart Turville (Author), David A Cooper (Author), Anthony D Kelleher (Author), Kazuo Suzuki (Author)
• Format: Book
• Published: Elsevier, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Transcriptional gene silencing (TGS) of mammalian genes can be induced by short interfering RNA (siRNA) targeting promoter regions. We previously reported potent TGS of HIV-1 by siRNA (PromA), which targets tandem NF-κB motifs within the viral 5'LTR. In this study, we screened a siRNA panel wit...