Structural modeling of the hERG potassium channel and associated drug interactions

• Autors principals: Jan Maly (Autor), Aiyana M. Emigh (Autor), Kevin R. DeMarco (Autor), Kazuharu Furutani (Autor), Jon T. Sack (Autor), Colleen E. Clancy (Autor), Igor Vorobyov (Autor), Vladimir Yarov-Yarovoy (Autor)
• Format: Llibre
• Publicat: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

The voltage-gated potassium channel, KV11.1, encoded by the human Ether-à-go-go-Related Gene (hERG), is expressed in cardiac myocytes, where it is crucial for the membrane repolarization of the action potential. Gating of the hERG channel is characterized by rapid, voltage-dependent, C-type inactiva...