Structural modeling of the hERG potassium channel and associated drug interactions

The voltage-gated potassium channel, KV11.1, encoded by the human Ether-à-go-go-Related Gene (hERG), is expressed in cardiac myocytes, where it is crucial for the membrane repolarization of the action potential. Gating of the hERG channel is characterized by rapid, voltage-dependent, C-type inactiva...

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Main Authors: Jan Maly (Author), Aiyana M. Emigh (Author), Kevin R. DeMarco (Author), Kazuharu Furutani (Author), Jon T. Sack (Author), Colleen E. Clancy (Author), Igor Vorobyov (Author), Vladimir Yarov-Yarovoy (Author)
Format: Book
Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
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