Nature-Inspired 1-Phenylpyrrolo[2,1-<i>a</i>]isoquinoline Scaffold for Novel Antiproliferative Agents Circumventing P-Glycoprotein-Dependent Multidrug Resistance

• Main Authors: Alisa A. Nevskaya (Author), Rosa Purgatorio (Author), Tatiana N. Borisova (Author), Alexey V. Varlamov (Author), Lada V. Anikina (Author), Arina Yu. Obydennik (Author), Elena Yu. Nevskaya (Author), Mauro Niso (Author), Nicola A. Colabufo (Author), Antonio Carrieri (Author), Marco Catto (Author), Modesto de Candia (Author), Leonid G. Voskressensky (Author), Cosimo D. Altomare (Author)
• Format: Book
• Published: MDPI AG, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Previous studies have shown that some lamellarin-resembling annelated azaheterocyclic carbaldehydes and related imino adducts, sharing the 1-phenyl-5,6-dihydropyrrolo[2,1-<i>a</i>]isoquinoline (1-Ph-DHPIQ) scaffold, are cytotoxic in some tumor cells and may reverse multidrug resistance (...