Neuroinflammation Upregulated Neuronal Toll-Like Receptors 2 and 4 to Drive Synucleinopathy in Neurodegeneration

• Main Authors: Lucia Yi-Ru Chung (Author), Yi-Ting Lin (Author), Chi Liu (Author), Yi-Cheng Tai (Author), Han-Yi Lin (Author), Chin-Hsien Lin (Author), Ching-Chow Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Parkinson's disease (PD) is characterized by intraneuronal α-synuclein aggregation called Lewy bodies and progressive dopaminergic neurodegeneration. Toll-like receptor (TLR) signaling is a major pathway mediating inflammation. The molecular link on how neuroinflammation upregulates...