Activation of Platelet NLRP3 Inflammasome in Crohn's Disease

• Main Authors: Ge Zhang (Author), He Chen (Author), Yifan Guo (Author), Wei Zhang (Author), Qiuyu Jiang (Author), Si Zhang (Author), Liping Han (Author), She Chen (Author), Ruyi Xue (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Patients with Crohn's disease (CD) are inclined to have platelet hyperactivity and an increased risk of intestinal micro-thrombosis. However, the mechanisms underlying platelet hyperactivity in CD are not well understood. We investigated the assembly of platelet NLRP3 inflammasome in patients w...