Synthesis, biological evaluation and molecular docking study of novel amide-coupled naphthalene scaffolds as potent inhibitors of bacterial recombinase A

• Main Authors: Ravi Kalariya (Author), Vikrant Pandya (Author), Nisarg Gohil (Author), Gargi Bhattacharjee (Author), Vijai Singh (Author), Dhanaji P. Rajani (Author), Rajesh Bhosale (Author), Jhillu Singh Yadav (Author)
• Formato: Livro
• Publicado em: Elsevier, 2022-12-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The development of antimicrobials having a unique mode of action is essential to solve multi-drug resistance challenges. Herein, we have designed and synthesized novel amide-coupled naphthalene scaffolds (4a-l) by acid-amine coupling reaction of 2-(naphthalen-1-yloxy)acetic acid with various amines....