A Reversibly Thermoresponsive, Theranostic Nanoemulgel for Tacrolimus Delivery to Activated Macrophages: Formulation and In Vitro Validation

• Main Authors: Riddhi Vichare (Author), Caitlin Crelli (Author), Lu Liu (Author), Amit Chandra Das (Author), Rebecca McCallin (Author), Fatih Zor (Author), Yalcin Kulahci (Author), Vijay S. Gorantla (Author), Jelena M. Janjic (Author)
• Format: Book
• Published: MDPI AG, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Despite long-term immunosuppression, organ transplant recipients face the risk of immune rejection and graft loss. Tacrolimus (TAC, FK506, Prograf^®) is an FDA-approved keystone immunosuppressant for preventing transplant rejection. However, it undergoes extensive first-pass me...