Flavopiridol Protects Bone Tissue by Attenuating RANKL Induced Osteoclast Formation

• Главные авторы: Zi'ang Hu (Автор), Yilei Chen (Автор), Lijiang Song (Автор), Jasper H. N. Yik (Автор), Dominik R. Haudenschild (Автор), Shunwu Fan (Автор)
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• Опубликовано: Frontiers Media S.A., 2018-05-01T00:00:00Z.
• Предметы: article
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Bone resorption and homeostasis is carried out by osteoclasts, whose differentiation and activity are regulated by the RANK/RANKL axis. Our previous studies using a mouse model of joint injury show that joint trauma induces local inflammation followed by bone remodeling. The transcription factor cyc...