Flavopiridol Protects Bone Tissue by Attenuating RANKL Induced Osteoclast Formation

• Main Authors: Zi'ang Hu (Author), Yilei Chen (Author), Lijiang Song (Author), Jasper H. N. Yik (Author), Dominik R. Haudenschild (Author), Shunwu Fan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bone resorption and homeostasis is carried out by osteoclasts, whose differentiation and activity are regulated by the RANK/RANKL axis. Our previous studies using a mouse model of joint injury show that joint trauma induces local inflammation followed by bone remodeling. The transcription factor cyc...