Donepezil ameliorates oxaliplatin-induced peripheral neuropathy via a neuroprotective effect

• Main Authors: Takehiro Kawashiri (Author), Shiori Shimizu (Author), Nao Shigematsu (Author), Daisuke Kobayashi (Author), Takao Shimazoe (Author)
• Format: Book
• Published: Elsevier, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxaliplatin induces severe peripheral neuropathy. The effect of donepezil, a drug used for treatment of Alzheimer's disease, on oxaliplatin-induced peripheral neuropathy was investigated using both in vivo and in vitro models. Donepezil effectively attenuated oxaliplatin- and cisplatin-induced...