Pharmacodynamic Evaluation of a Single Dose versus a 24-Hour Course of Multiple Doses of Cefazolin for Surgical Prophylaxis

• Main Authors: Aaron Heffernan (Author), Jowana Alawie (Author), Steven C Wallis (Author), Saiyuri Naicker (Author), Santosh Adiraju (Author), Jason A. Roberts (Author), Fekade Bruck Sime (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The optimal perioperative duration for the administration of cefazolin and other prophylactic antibiotics remains unclear. This study aimed to describe the pharmacodynamics of cefazolin for a single 2 g dose versus a 24 h course of a 2 g single dose plus a 1 g eight-hourly regimen against methicilli...