Mycolactone diffuses into the peripheral blood of Buruli ulcer patients--implications for diagnosis and disease monitoring.

• Main Authors: Fred S Sarfo (Author), Fabien Le Chevalier (Author), N'Guetta Aka (Author), Richard O Phillips (Author), Yaw Amoako (Author), Ivo G Boneca (Author), Pascal Lenormand (Author), Mireille Dosso (Author), Mark Wansbrough-Jones (Author), Romain Veyron-Churlet (Author), Laure Guenin-Macé (Author), Caroline Demangel (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mycobacterium ulcerans, the causative agent of Buruli ulcer (BU), is unique among human pathogens in its capacity to produce a polyketide-derived macrolide called mycolactone, making this molecule an attractive candidate target for diagnosis and disease monitoring. Whether mycolactone diffuses from...