Structural and functional characterization of a monoclonal antibody blocking TIGIT

• Main Authors: Bo-Seong Jeong (Author), Hyemi Nam (Author), Jeewon Lee (Author), Hye-Young Park (Author), Ki Joon Cho (Author), Joong Hyuk Sheen (Author), Eunjung Song (Author), Meesook Oh (Author), Sunggeun Lee (Author), Hyemin Choi (Author), Jung-Eun Yang (Author), Munkyung Kim (Author), Byung-Ha Oh (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

TIGIT is an immune checkpoint receptor that is expressed on subsets of activated T cells and natural killer (NK) cells. Several ligands for TIGIT, including poliovirus receptor (PVR), are expressed on cancer cells and mediate inhibitory signaling to suppress antitumor activities of the immune cells....