Tissue Type Differences in ABCB1 Expression and Paclitaxel Tissue Pharmacokinetics in Patients With Esophageal Cancer

• Main Authors: Ruben A. G. van Eerden (Author), Leni van Doorn (Author), Femke M. de Man (Author), Niels Heersche (Author), Michail Doukas (Author), Thierry P. P. van den Bosch (Author), Esther Oomen-de Hoop (Author), Peter de Bruijn (Author), Sander Bins (Author), Eman Ibrahim (Author), Suzan Nikkessen (Author), Lena E. Friberg (Author), Stijn L. W. Koolen (Author), Manon C. W. Spaander (Author), Ron H. J. Mathijssen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Data from previous work suggests that there is no correlation between systemic (plasma) paclitaxel exposure and efficacy in patients treated for esophageal cancer. In this trial, we investigated ATP-binding cassette efflux transporter expression and intratumoral pharmacokinetics of pacli...