Hepatic and intestinal biotransformation gene expression and drug disposition in a dextran sulfate sodium-induced colitis mouse model

We examined the impact of gut inflammation on the expression of cytochrome P450 (P450) and other biotransformation genes in male mice using a dextran sulfate sodium (DSS)-induced colitis model. Several P450 isoforms, including CYP1A, CYP2B, CYP2C, and CYP3A, were down-regulated, accompanied by decre...

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Main Authors: Xiaoyu Fan (Author), Xinxin Ding (Author), Qing-Yu Zhang (Author)
Format: Book
Published: Elsevier, 2020-01-01T00:00:00Z.
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3rd Floor Main Library

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