Soluble CD80 oral delivery by recombinant Lactococcus suppresses tumor growth by enhancing antitumor immunity

• Main Authors: Ziqing Lin (Author), Yanqing Tang (Author), Zerong Chen (Author), Simin Li (Author), Xueyan Xu (Author), Xufeng Hou (Author), Zhenhui Chen (Author), Junjie Wen (Author), Weisen Zeng (Author), Xiaojing Meng (Author), Hongying Fan (Author)
• Format: Book
• Published: Wiley, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract CD80 is an important co‐stimulatory molecule that participates in the immune response. Soluble CD80 can induce T cell activation and overcome PDL1‐mediated immune suppression. In this study, we aimed to construct recombinant Lactococcus lactis for oral delivery of the soluble CD80 (hsCD80)...