How Does the Addition of Kollidon^®VA64 Inhibit the Recrystallization and Improve Ezetimibe Dissolution from Amorphous Solid Dispersions?

• Main Authors: Joanna Szafraniec-Szczęsny (Author), Agata Antosik-Rogóż (Author), Mateusz Kurek (Author), Karolina Gawlak (Author), Anna Górska (Author), Sebastian Peralta (Author), Justyna Knapik-Kowalczuk (Author), Daniel Kramarczyk (Author), Marian Paluch (Author), Renata Jachowicz (Author)
• Format: Book
• Published: MDPI AG, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Amorphization serves as a strategy for the improvement of poor dissolution characteristics of many drug compounds. However, in many formulations the content of polymeric stabilizer is high, which is undesirable from the perspective of future applications. Thus, studying the composition-dependent sta...