Effects of ceramide kinase knockout on lipopolysaccharide-treated sepsis-model mice: Changes in serum cytokine/chemokine levels and increased lethality

• Main Authors: Ai Tanaka (Author), Takuya Honda (Author), Masataka Yasue (Author), Risa Yamazaki (Author), Hiroto Hatakeyama (Author), Akihiro Hisaka (Author), Masato Mashimo (Author), Takafumi Kohama (Author), Hiroyuki Nakamura (Author), Toshihiko Murayama (Author)
• Format: Book
• Published: Elsevier, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ceramide, a central molecule of sphingolipid metabolism, is phosphorylated to ceramide-1-phosphate (C1P) by ceramide kinase (CerK). The CerK/C1P pathway regulates many cellular functions, but its roles in immune/inflammation-related (IIR) diseases in vivo are not well known. Sepsis is an acute syste...