Effects of ceramide kinase knockout on lipopolysaccharide-treated sepsis-model mice: Changes in serum cytokine/chemokine levels and increased lethality

• المؤلفون الرئيسيون: Ai Tanaka (مؤلف), Takuya Honda (مؤلف), Masataka Yasue (مؤلف), Risa Yamazaki (مؤلف), Hiroto Hatakeyama (مؤلف), Akihiro Hisaka (مؤلف), Masato Mashimo (مؤلف), Takafumi Kohama (مؤلف), Hiroyuki Nakamura (مؤلف), Toshihiko Murayama (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2022-09-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Ceramide, a central molecule of sphingolipid metabolism, is phosphorylated to ceramide-1-phosphate (C1P) by ceramide kinase (CerK). The CerK/C1P pathway regulates many cellular functions, but its roles in immune/inflammation-related (IIR) diseases in vivo are not well known. Sepsis is an acute syste...