Novel Peripherally Restricted Cannabinoid 1 Receptor Selective Antagonist TXX-522 with Prominent Weight-Loss Efficacy in Diet Induced Obese Mice

• Main Authors: Wei Chen (Author), Fengchun Shui (Author), Cheng Liu (Author), Xinbo Zhou (Author), Wei Li (Author), Zhibing Zheng (Author), Wei Fu (Author), Lili Wang (Author)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2017-10-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

The clinical development of the first generation of globally active cannabinoid 1 receptor (CB1R) antagonists was suspended because of their adverse neuropsychiatric effects. Selective blockade of peripheral CB1Rs has the potential to provide a viable strategy for the treatment of severe obesity whi...