Novel Peripherally Restricted Cannabinoid 1 Receptor Selective Antagonist TXX-522 with Prominent Weight-Loss Efficacy in Diet Induced Obese Mice

The clinical development of the first generation of globally active cannabinoid 1 receptor (CB1R) antagonists was suspended because of their adverse neuropsychiatric effects. Selective blockade of peripheral CB1Rs has the potential to provide a viable strategy for the treatment of severe obesity whi...

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Bibliographic Details
Main Authors: Wei Chen (Author), Fengchun Shui (Author), Cheng Liu (Author), Xinbo Zhou (Author), Wei Li (Author), Zhibing Zheng (Author), Wei Fu (Author), Lili Wang (Author)
Format: Book
Published: Frontiers Media S.A., 2017-10-01T00:00:00Z.
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