The glutamine synthetase of Trypanosoma cruzi is required for its resistance to ammonium accumulation and evasion of the parasitophorous vacuole during host-cell infection.

• Main Authors: Marcell Crispim (Author), Flávia Silva Damasceno (Author), Agustín Hernández (Author), María Julia Barisón (Author), Ismael Pretto Sauter (Author), Raphael Souza Pavani (Author), Alexandre Santos Moura (Author), Elizabeth Mieko Furusho Pral (Author), Mauro Cortez (Author), Maria Carolina Elias (Author), Ariel Mariano Silber (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Trypanosoma cruzi, the etiological agent of Chagas disease, consumes glucose and amino acids depending on the environmental availability of each nutrient during its complex life cycle. For example, amino acids are the major energy and carbon sources in the intracellular stages of the T. cruzi parasi...