CB2-mediated attenuation of nucleus pulposus degeneration via the amelioration of inflammation and oxidative stress in vivo and in vitro

• Main Authors: Xiaoqiang Cheng (Author), Jiayi Lin (Author), Zhanghuan Chen (Author), Yubo Mao (Author), Xiexin Wu (Author), Congxin Xu (Author), Jiacheng Du (Author), Zhongchen Dong (Author), Huilin Yang (Author), Feng Zhou (Author), Dechun Geng (Author)
• Format: Book
• Published: BMC, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Nucleus pulposus cell (NPC) degeneration is widely accepted as one of the major causes of intervertebral disc (IVD) degeneration (IVDD). The pathogenesis of IVDD is complex and consists of inflammation, oxidative stress, and the loss of extracellular matrix (ECM). Cannabinoid typ...