Lactone Stabilized by Crosslinked Cyclodextrin Metal-Organic Frameworks to Improve Local Bioavailability of Topotecan in Lung Cancer

• Main Authors: Ting Xiong (Author), Tao Guo (Author), Yaping He (Author), Zeying Cao (Author), Huipeng Xu (Author), Wenting Wu (Author), Li Wu (Author), Weifeng Zhu (Author), Jiwen Zhang (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The protection of unstable anticancer molecules and their delivery to lesions are challenging issues in cancer treatment. Topotecan (TPT), a classic cytotoxic drug, is widely used for treating refractory lung cancer. However, the therapeutic effects of TPT are jeopardized by its active lactone form...