Halothane Sensitizes the Guinea-Pig Heart to Pharmacological IKr Blockade: Comparison With Urethane Anesthesia

• Main Authors: Yasue Sakaguchi (Author), Atsushi Sugiyama (Author), Shuji Takao (Author), Yasuki Akie (Author), Akira Takahara (Author), Keitaro Hashimoto (Author)
• Format: Book
• Published: Elsevier, 2005-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Potential utility of halothane-anesthetized guinea pigs for detecting drug-induced repolarization delay was analyzed in comparison with urethane-anesthesia (n = 4 for both groups). Basal QT interval was significantly greater under halothane-anesthesia than urethane-anesthesia (192 ± 7 vs 132 ± 5 ms,...