Heme acts through the Bach1b/Nrf2a-MafK pathway to regulate exocrine peptidase precursor genes in porphyric zebrafish

• Main Authors: Shuqing Zhang (Author), Minrui Xu (Author), Jian Huang (Author), Lili Tang (Author), Yanqing Zhang (Author), Jingyao Wu (Author), Shuo Lin (Author), Han Wang (Author)
• Format: Book
• Published: The Company of Biologists, 2014-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Using a zebrafish model of hepatoerythropoietic porphyria (HEP), we identify a previously unknown mechanism underlying heme-mediated regulation of exocrine zymogens. Zebrafish bach1b, nrf2a and mafK are all expressed in the zebrafish exocrine pancreas. Overexpression of bach1b or knockdown of nrf2a...