Chelerythrine-Induced Apoptotic Cell Death in HepG2 Cells Involves the Inhibition of Akt Pathway and the Activation of Oxidative Stress and Mitochondrial Apoptotic Pathway

• 主要な著者: Yanling Lin (著者), Qinzhi Zhang (著者), Baofu Xie (著者), Haiyang Jiang (著者), Jianzhong Shen (著者), Shusheng Tang (著者), Chongshan Dai (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2022-09-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Chelerythrine (CHE) is a majorly harmful isoquinoline alkaloid ingredient in <i>Chelidonium majus</i> that could trigger potential hepatotoxicity, but the pivotal molecular mechanisms remain largely unknown. In the present study, CHE-induced cytotoxicity and the underlying toxic mechanis...