Chelerythrine-Induced Apoptotic Cell Death in HepG2 Cells Involves the Inhibition of Akt Pathway and the Activation of Oxidative Stress and Mitochondrial Apoptotic Pathway

• Main Authors: Yanling Lin (Author), Qinzhi Zhang (Author), Baofu Xie (Author), Haiyang Jiang (Author), Jianzhong Shen (Author), Shusheng Tang (Author), Chongshan Dai (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chelerythrine (CHE) is a majorly harmful isoquinoline alkaloid ingredient in <i>Chelidonium majus</i> that could trigger potential hepatotoxicity, but the pivotal molecular mechanisms remain largely unknown. In the present study, CHE-induced cytotoxicity and the underlying toxic mechanis...