Genetic Variation in Autophagy-Related Genes Influences the Risk and Phenotype of Buruli Ulcer.

• Main Authors: Carlos Capela (Author), Ange Dodji Dossou (Author), Rita Silva-Gomes (Author), Ghislain Emmanuel Sopoh (Author), Michel Makoutode (Author), João Filipe Menino (Author), Alexandra Gabriel Fraga (Author), Cristina Cunha (Author), Agostinho Carvalho (Author), Fernando Rodrigues (Author), Jorge Pedrosa (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Buruli ulcer (BU) is a severe necrotizing human skin disease caused by Mycobacterium ulcerans. Clinically, presentation is a sum of these diverse pathogenic hits subjected to critical immune-regulatory mechanisms. Among them, autophagy has been demonstrated as a cellular process of critical importan...