Preparation and In Vitro/In Vivo Evaluation of Orally Disintegrating/Modified-Release Praziquantel Tablets

• Main Authors: Xuemei Wen (Author), Zhaoyou Deng (Author), Yangfeng Xu (Author), Guoqing Yan (Author), Xin Deng (Author), Liqin Wu (Author), Qiuling Liang (Author), Fang Fang (Author), Xin Feng (Author), Meiling Yu (Author), Jiakang He (Author)
• Format: Book
• Published: MDPI AG, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study was designed to develop orally disintegrating/sustained-release praziquantel (PZQ) tablets using the hot-melt extrusion (HME) technique and direct compression, and subsequently evaluate their release in in vitro and in vivo pharmacokinetics. For the extrusion process, hypromellose acetate...