Molecular Mechanisms of the Teratogenic Effects of Thalidomide

• Main Authors: Tomoko Asatsuma-Okumura (Author), Takumi Ito (Author), Hiroshi Handa (Author)
• Formato: Libro
• Publicado: MDPI AG, 2020-05-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Thalidomide was sold worldwide as a sedative over 60 years ago, but it was quickly withdrawn from the market due to its teratogenic effects. Thalidomide was later found to have therapeutic effects in several diseases, although the molecular mechanisms remained unclear. The discovery of cereblon (CRB...