Endocrine and metabolic complications in children and adolescents with Sickle Cell Disease: an Italian cohort study

• Main Authors: V. Mandese (Author), E. Bigi (Author), P. Bruzzi (Author), G. Palazzi (Author), B. Predieri (Author), L. Lucaccioni (Author), M. Cellini (Author), L. Iughetti (Author)
• Format: Book
• Published: BMC, 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Children with Sickle Cell Disease (SCD) show endocrine complications and metabolic alterations. The physiopathology of these conditions is not completely understood: iron overload due to chronic transfusions, ischemic damage, and inflammatory state related to vaso-occlusive crise...