A Phase I Clinical Study Comparing the Tolerance, Immunogenicity, and Pharmacokinetics of Proposed Biosimilar BAT1806 and Reference Tocilizumab in Healthy Chinese Men

• Main Authors: Hong Zhang (Author), Hong Wang (Author), Haijing Wei (Author), Hong Chen (Author), Jingrui Liu (Author), Cuiyun Li (Author), Xiaoxue Zhu (Author), Xiaojiao Li (Author), Jinchen Yu (Author), Yinbo Zhou (Author), Xiaolei Yang (Author), Zhaohe Wang (Author), Min Wu (Author), Yanhua Ding (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The study aimed to explore the bioequivalence of a proposed biosimilar BAT1806 to its reference products marketed in the EU and US (RoActemra-EU and Actemra-US) among healthy Chinese men. The tolerance, immunogenicity, and pharmacokinetics (PK) of the three drugs were also investigated.Me...